Panagiotis Ntziachristos

This study identifies SOX11 as a driver of γδ-like T-cell acute lymphoblastic leukemia, showing its cooperation with LMO2 and MYCN to promote leukemogenesis.

The paper identifies cancer-specific CTCF binding patterns across six cancer types and shows they are linked to oncogenic transcriptional changes without always involving DNA methylation or mutations.

The paper improves Hi-C contact matrix reproducibility using fused two-dimensional lasso, identifies TAD boundaries with varying insulation strength, and shows super-enhancers are preferentially insulated by strong boundaries, which are frequently co-duplicated in cancer.

HiC-bench provides a comprehensive and reproducible platform for Hi-C data analysis, enabling parameter exploration and benchmarking of different tools and methods.