Cancer BiologyScience SignalingPeer-reviewed
Targeting GOF p53 and c-MYC through LZK Inhibition or Degradation Suppresses Head and Neck Tumor Growth
Amy L. Funk, Meghri Katerji, Marwa M. Afifi…·John Brognard
This study identifies LZK as a therapeutic target in HNSCC by showing its regulation of c-MYC and GOF p53, and demonstrates PROTAC-mediated degradation as a potential treatment.
12 citations