Matrix-rigidity cooperates with biochemical cues in M2 macrophage activation through increased nuclear deformation and chromatin accessibility
Seung Jae Shin, Buuvee Bayarkhangai, Khaliunsarnai Tsogtbaatar, Meng Yuxuan, Sang‐Hyun Kim, Yong‐Jae Kim, Ali Taghizadeh, Daesan Kim, Dong‐Hwee Kim, Jung‐Hwan Lee, Jeongeun Hyun, Hae‐Won Kim
This study shows matrix rigidity enhances M2 macrophage activation by altering nuclear mechanics and chromatin accessibility through cooperation with biochemical signals like IL4/13.
Advanced Science · Jan 19, 2025Peer-reviewedBioengineering