Cell BiologybioRxivPreprint
Interplay of Cullin5-HECTD3 ubiquitin ligases regulates stability of CRAF mutant associated with hypertrophy
Somesh Roy, Soumita Mukherjee, Atin Kumar Mandal
The paper identifies HECTD3 and Cul5-HECTD3 axis regulation of CRAF mutant stability in hypertrophy, showing Hsp90 primes substrates for ubiquitination and Cul5 controls ligase turnover.
DOI 10.64898/2026.05.23.727451