Leishmania parasite arginine deprivation response pathway influences the host macrophage lysosomal arginine sensing machinery
Evanka Madan, Nirmal Kumar Ganguly, Madhu Puri, Harsh Pawar, Angamuthu Selvapandiyan, Rohini Muthuswami, Dan Zilberstein, Rentala Madhubala
This study shows that Leishmania donovani activates the host SLC38A9 arginine sensing pathway in macrophages, which is critical for maintaining parasite arginine transporter LdAAP3 levels and intracellular growth.
Medical Research Archives · Jan 1, 2024Peer-reviewedMolecular Biology