Rohini Muthuswami

Purification and characterization of recombinant Rtt109, a fungus-specific histone acetyltransferase, from Candida albicans

This study characterizes the recombinant Rtt109 histone acetyltransferase from Candida albicans, identifies its functional requirements, and screens for potential inhibitors with clinical implications.

Candida albicans Snf2 modulates the response to DNA damage by regulating gene expression and uptake of the genotoxic stressors

This study shows that Candida albicans Snf2 regulates DNA damage response by affecting gene expression and drug resistance.

BRG1 cooperates with PLK1 to regulate dormant origin activation during S phase.

This study identifies BRG1's role in regulating dormant replication origin activation by interacting with PLK1, showing reduced replication fork progression upon BRG1 depletion.

Antifungal therapeutic potential of Candida albicans Fun30: screening and validation of novel inhibitors against Candida albicans

This study identifies CaFun30 as a potential antifungal target by screening a small molecule library and validating F1853-0039 as a lead inhibitor against C. albicans.

Leishmania parasite arginine deprivation response pathway influences the host macrophage lysosomal arginine sensing machinery

This study shows that Leishmania donovani activates the host SLC38A9 arginine sensing pathway in macrophages, which is critical for maintaining parasite arginine transporter LdAAP3 levels and intracellular growth.

RTT109 AND Fun30 proteins mediate epigenetic regulation of the DNA damage response pathway in C. albicans

The paper investigates the role of Fun30 and Rtt109 in regulating DNA damage response genes in C. albicans through histone acetylation and chromatin remodeling.

PICH, an ATP-dependent chromatin remodeling protein, transcriptionally co-regulates oxidative stress response.

This study shows PICH, an ATP-dependent chromatin remodeler, co-regulates oxidative stress response with Nrf2 by modulating antioxidant gene expression and interacting with H3K27ac.

Altering mammalian transcription networking with ADAADi: An inhibitor of ATP-dependent chromatin remodeling

This paper introduces ADAADi, an inhibitor of ATP-dependent chromatin remodeling, showing anti-tumor effects by altering transcriptional networks and inducing apoptosis.

Regulation of ATM and ATR by SMARCAL1 and BRG1

This study shows SMARCAL1 and BRG1 regulate ATM/ATR transcription, which is essential for the G2/M checkpoint response to DNA damage.