Evanka Madan

This study shows that degrading host p38-MAPK with NR-7h reduces parasite load in Leishmania and Plasmodium infections and enhances antiparasitic therapy when combined with Amphotericin B.

This study identifies inflammation-responsive s-acylation of key antioxidants in microglia, revealing their role in redox flexibility and schizophrenia pathology.

This paper evaluates PF-543, a SphK1 inhibitor, against Leishmania donovani, showing reduced parasite load and enhanced immune response both in vitro and in vivo.

This study identifies SphK1 as a druggable target in human macrophages for anti-leishmanial therapy by showing its role in promoting Leishmania donovani survival through immune evasion and cell fate regulation.

The paper shows that diet-induced metabolic syndrome in mice leads to hypoxic response and mitochondrial dysfunction in aortic tissue, linked to elevated IL-4 and ADMA levels.

This study shows that Leishmania donovani activates the host SLC38A9 arginine sensing pathway in macrophages, which is critical for maintaining parasite arginine transporter LdAAP3 levels and intracellular growth.

This study shows that S1P from host erythrocytes regulates PfHDAC-1 activity, affecting transcription of genes related to gametocytogenesis, virulence, and proliferation in Plasmodium falciparum.