Dan Zilberstein

Leishmania parasite arginine deprivation response pathway influences the host macrophage lysosomal arginine sensing machinery

This study shows that Leishmania donovani activates the host SLC38A9 arginine sensing pathway in macrophages, which is critical for maintaining parasite arginine transporter LdAAP3 levels and intracellular growth.

Macrophage metallothioneins participate in the antileishmanial activity of antimonials

This study shows that macrophage metallothioneins (MTs) are involved in antileishmanial activity of antimonials by detoxifying xenobiotics and enhancing parasite killing.