Christopher F. Chabris

Family-based GWAS meta-analysis of 34 phenotypes shows standard GWAS effects carry sizeable confounding uncorrelated with direct genetic effects, while assortative mating likely inflates SNP heritability and genetic correlations.

This study uses EHR data to estimate TRD probability and identifies two genome-wide significant loci linked to metabolic traits, suggesting shared biology with related conditions.

The paper examines the association between psychiatric polygenic scores and healthcare utilization and comorbidity burden in individuals of European ancestry, finding significant links for major depressive disorder.

This study evaluates polygenic risk scores for schizophrenia in electronic health records, finding strong associations with schizophrenia and pleiotropic effects on other psychiatric and medical conditions.