Author
University of California, Los AngelesORCID 0000-0003-3144-0757Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Robel G. Alemu, Anastasia Terskaya, Matthew Howell…·Aysu Okbay
The paper updates a polygenic index repository with more phenotypes, datasets, and improved causal inference methods, enhancing predictive performance and interpretability.
Tammy Tan, Hariharan Jayashankar, Junming Guan…·Alexander I. Young
Family-based GWAS meta-analysis of 34 phenotypes shows standard GWAS effects carry sizeable confounding uncorrelated with direct genetic effects, while assortative mating likely inflates SNP heritability and genetic correlations.
Junming Guan, Seyed Moeen Nehzati, Daniel Jacob Benjamin, Alexander I. Young
The paper introduces novel estimators for family-based GWAS that increase power and robustness to population structure by improving imputation of missing parent genotypes and using a linear-mixed model.