Molecular BiologyMolecular CellPeer-reviewed
ER-directed TREX1 limits cGAS recognition of micronuclei
Lisa Mohr, Eléonore Toufektchan, Patrick von Morgen…·John Maciejowski
This study shows TREX1 limits cGAS recognition of micronuclear DNA by degrading it after micronuclear envelope rupture, and a TREX1 mutation disrupts this process, enhancing immune sensing.
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