Author

Kevan Chu

Memorial Sloan Kettering Cancer CenterORCID 0009-0009-5151-3096Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Eléonore ToufektchaniD· 2 shared John MaciejowskiiD· 2 shared Aakanksha R. KapooriD· 1 shared Aikaterini ChatzipliiD· 1 shared Alexandra DananbergiD· 1 shared Dmitry A. GordeniniD· 1 shared Elizabeth Granowsky· 1 shared Himari Imaya Gunasinghe· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMolecular Biology

Eléonore ToufektchanORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintAug 5, 2025

Concurrent genetic and non-genetic resistance mechanisms to KRAS inhibition in CRC

Salvador Alonso, Kevan Chu, Marie J. Parsons…·Lukas E. Dow

This study identifies genetic and non-genetic resistance mechanisms to KRAS inhibition in CRC using single-cell spatial transcriptomics and exome sequencing, revealing inflammatory and fetal-like transcriptional signatures associated with resistance.

4 citations

humanbulk RNA-seq

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Molecular BiologyMolecular CellPeer-reviewedJan 20, 2021

ER-directed TREX1 limits cGAS recognition of micronuclei

Lisa Mohr, Eléonore Toufektchan, Patrick von Morgen…·John Maciejowski

This study shows TREX1 limits cGAS recognition of micronuclear DNA by degrading it after micronuclear envelope rupture, and a TREX1 mutation disrupts this process, enhancing immune sensing.

209 citationstop 1%

humanexperimental assay

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Molecular BiologyNature GeneticsPeer-reviewedJul 27, 2020

APOBEC3B-dependent kataegis and TREX1-driven chromothripsis in telomere crisis

John Maciejowski, Aikaterini Chatzipli, Alexandra Dananberg…·Titia de Lange

This study identifies TREX1 and APOBEC3B as key drivers of chromothripsis and kataegis during telomere crisis in cancer.

169 citationstop 1%

experimental assay

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