Tomasz Woźniak

The paper uses CRISPR/Cas9 screens to identify essential MYC binding sites and target genes in cancer cells, revealing key genes involved in cancer pathways.

TransCRISPR designs sgRNAs targeting DNA motifs in user-provided genomic regions across 30 genomes, validated for disrupting MYC binding sites and affecting gene expression.

RNAlign2D rapidly aligns RNA sequences by converting them to pseudo-amino acids and using MUSCLE, producing accurate alignments for RNA classification and function prediction.

The paper identifies distinct mRNA targets and protein cofactors regulated by PUM1 and PUM2 in human male germ cells, revealing functional divergence in their RNA regulatory roles.