Erkut Ilaslan

Multi-omic screening identifies RBMXL3 as a primate-specific RNA-binding protein and candidate regulator of RNA metabolism in human spermatogenesis

This study identifies RBMXL3 as a primate-specific RNA-binding protein that regulates RNA metabolism and suppresses LINE-1 retrotransposition in human spermatogenesis.

The RNA helicase DDX53 (CAGE) contributes to RNA metabolism in a human germ cell model

The paper investigates DDX53's role in human germ cells using TCam-2 cells, showing its involvement in RNA metabolism, splicing, and potential interactions with RNA molecules.

Major waves of H2A.Z incorporation during mouse oogenesis

The paper maps H2A.Z incorporation during mouse oogenesis, identifying distinct patterns and their relationship with epigenetic marks and transposable elements.

N6-Methyladenosine Safeguards Mouse and Human Germline Competence

This study shows that reducing N6-methyladenosine (m6A) levels in mouse and human pluripotent cells disrupts germline entry by altering signaling pathways, chromatin states, and gene expression.

A male infertility mutation reverts NANOS1 activity from anti-apoptotic to pro-apoptotic by disrupting repression of GADD45A, GADD45B, GADD45G and RHOB genes

The paper identifies a NANOS1 mutation that switches its function from anti-apoptotic to pro-apoptotic in human germ cells by disrupting repression of pro-apoptotic genes.

Human PUM1 and PUM2 exhibit regulation of divergent mRNA targets in male germ cells

The paper identifies distinct mRNA targets and protein cofactors regulated by PUM1 and PUM2 in human male germ cells, revealing functional divergence in their RNA regulatory roles.

Kinesin KIF18A is a novel PUM regulated target promoting mitotic progression and survival of human male germ cell line - TCam-2

This study identifies KIF18A as a PUM-regulated gene that promotes proliferation and survival in human male germ cell line TCam-2 cells.