KIR Expression Defines a Transcriptionally Distinct CD8+ T-cell Population that Confounds Antigen-Specific T-cell Detection
A Kongsgaard, Janine Sophie Kemming, Sofie Ramskov, Annie Borch, Yogesh Basavaraju, Alberte Obitz Mogensen, Tsvetanka Rangelova, Mohammad Kadivar, Sine Reker Hadrup, Sunil Kumar Saini
This paper identifies KIR-mediated pHLA-C binding as a confounder in T-cell analysis and provides a method to distinguish it from TCR-specific binding.
bioRxiv · Jul 20, 2026 · PreprintImmunology