Ca2+-calmodulin regulates Kv7.1 channel gating by allosterically interfering with its inactivation path
Nitzan Daus, Flavio Costa, Carlo Guardiani, Maya Lipinsky, Ariel Ben-Bassat, Yoni Haitin, Alberto Giacomello, Bernard Attali
The paper identifies the inactivation paths of Kv7.1 channels and shows how Ca2+-calmodulin prevents inactivation through allosteric interference.
bioRxiv · Sep 2, 2025 · PreprintBiophysics