Lars Schlotawa

A human-supervised multi-agent LLM system covered drug repurposing from knowledge graph building to assay analysis in three case studies; retrospective COVID-19 screen AUC-ROC 0.986 without predefined thresholds.

This paper develops a novel lentiviral vector for gene therapy of MLD that achieves high ARSA activity with minimal genomic integrations, improving safety and efficacy in preclinical models.

This study shows that SUMF1 gene therapy via hematopoietic stem cell transplant improves biochemical and functional outcomes in a mouse model of Multiple Sulfatase Deficiency.