Flavio Ballante

This study identifies RMDPi-1 as an autophagy enhancer that inhibits RMDP phosphatases, increasing ROS and autophagy in plants, thereby improving stress resilience.

A human-supervised multi-agent LLM system covered drug repurposing from knowledge graph building to assay analysis in three case studies; retrospective COVID-19 screen AUC-ROC 0.986 without predefined thresholds.

The paper identifies host-targeting antivirals against SARS-CoV-2 using morphological profiling, finding compounds that reverse infected cell phenotypes and validate host processes hijacked by viruses.

The paper develops two annotation pipelines and dashboards to integrate chemical and bioactivity data for drug repurposing, validated on a compound library with over 5000 compounds.