Adeline Durand

This study identifies the pentose phosphate pathway's role in regulating myeloid versus lymphoid lineage specification in hematopoietic stem and progenitor cells through metabolic state-fate mapping.

The paper introduces OneCell CUT&Tag, a single-cell multi-omics method that captures chromatin, transcriptome, and surface marker data, revealing epigenomic reprogramming during mammary gland basal-to-luminal transition.

This paper develops a single-nucleus multimodal framework to analyze transcriptional and histone modification landscapes in ovarian cancer, revealing epigenomic priming of chemoresistant states and its impact on treatment outcomes.