In vivo xenogenic reconstitution of human alveolar epithelial architecture and function
Akira Yamagata, Satoshi Konishi, Satoshi Ikeo, Hiroshi Moriyama, Senye Takahashi, Naoyuki Sone, Satoshi Hamada, Atsushi Saito, Takashi Kawaguchi, Shu Hisata, Akira Niwa, Toshiaki Kikuchi, Hirofumi Chiba, Megumu K. Saito, Koichi Hagiwara, , Shimpei Gotoh
This paper develops a chimeric mouse model to replicate human alveolar epithelial architecture and function using hiPSC-derived lung progenitors.
bioRxiv · Jan 12, 2026 · PreprintDevelopmental Biology