Cell Type-Specific Effects of miR-21 Loss Attenuate Tumor Progression in MYC-Driven Prostate Cancer
Kenji Zennami, Mindy Kim Graham, Shireen Chikara, Polina Sysa‐Shah, Fatima Rafiqi, Rulin Wang, Bulouere Abel, Qizhi Zeng, Timothy E. G. Krueger, William Nathaniel Brennen, Sudipto Ganguly, Jelani C. Zarif, Brian Wesley Simons, Theodore L. DeWeese, Angelo Michael De Marzo, , Shawn E. Lupold
This study shows that loss of miR-21 in MYC-driven prostate cancer reduces tumor progression by affecting cell-type-specific gene regulation and immune infiltration.
bioRxiv · May 14, 2025 · PreprintCancer Biology