Author

Brian Wesley Simons

Baylor College of MedicineORCID 0000-0003-0644-211XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Ahmed M. ElkhananyiD· 1 shared Andrew Davis· 1 shared Angela R. OmilianiD· 1 shared Angelo Michael De MarzoiD· 1 shared Arun SreekumariD· 1 shared Arundati Rao· 1 shared Badrajee PiyarathnaiD· 1 shared Balasubramanyam KaranamiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

Ahmed M. ElkhananyORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJan 30, 2026

AADAT-Driven Metabolic Control of Malate and CoQ10 Shapes Immune Evasion in Triple-Negative Breast Cancer

Megha Chatterjee, Franklin Gu, Susmita Samanta…·Arun Sreekumar

This paper identifies AADAT as a metabolic immune checkpoint in TNBC that promotes immune evasion by regulating malate and CoQ10, and shows that malate supplementation can reverse immunotherapy resistance.

DOI 10.64898/2026.01.28.702389

humanmouse

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Cancer BiologybioRxivPreprintMay 14, 2025

Cell Type-Specific Effects of miR-21 Loss Attenuate Tumor Progression in MYC-Driven Prostate Cancer

Kenji Zennami, Mindy Kim Graham, Shireen Chikara…·Shawn E. Lupold

This study shows that loss of miR-21 in MYC-driven prostate cancer reduces tumor progression by affecting cell-type-specific gene regulation and immune infiltration.

1 citation

mousescRNA-seq

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