Author

Cynthia L. Darnell

Duke UniversityORCID 0000-0002-7489-8584Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:Bayesian inference· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Assay:metabolomics· 1 Approach:mixed model· 1 Organism:multiple species· 1 Assay:proteomics· 1

Frequent Co-Authors

Amy SchmidiD· 2 shared Angie Vreugdenhil· 1 shared Francesca M. L. Bushell· 1 shared Mar Martínez-PastoriD· 1 shared Peter A. LundiD· 1 shared Peter D. TonneriD· 1 shared Scott C. SchmidleriD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

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7 top collaborators · 13 mutual co-author links

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2 shared papersMicrobiology

Amy SchmidORCID

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2 papers

Recent·Most cited

MicrobiologyMolecular Biology of the CellPeer-reviewedMay 21, 2025

Rapid rewiring of an archaeal transcription factor function via flexible cis-trans interactions

Mar Martínez-Pastor, Cynthia L. Darnell, Angie Vreugdenhil, Amy Schmid

The paper shows that the archaeal transcription factor RosR has divergent functions across species despite strong sequence conservation, likely due to flexible cis-trans interactions.

5 citations

multiple speciesexperimental assay

𝕏 PostBluesky

Systems BiologybioRxivPreprintOct 4, 2019

A Bayesian Non-parametric Mixed-Effects Model of MicrobialPhenotypes

Peter D. Tonner, Cynthia L. Darnell, Francesca M. L. Bushell…·Scott C. Schmidler

This paper introduces a Bayesian non-parametric model to analyze microbial growth data, accounting for random effects and improving accuracy in estimating biological effects.

DOI 10.1101/793174

proteomicsmetabolomics

𝕏 PostBluesky