BiochemistryProtein SciencePeer-reviewed
An Engineered IGF2 Mutant for Lysosomal Targeting Chimeras Development and Membrane Proteins Degradation
Yanchao Pan, Qing Xiang, Kai Deng…·Weijun Shen
This paper introduces eiLYTACs, an engineered IGF2-based technology that degrades membrane proteins and inhibits tumor growth by avoiding IGF1R activation.
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