Long-read cDNA sequencing reveals novel isoforms and spliceosome-mutant-enriched transcripts in AML and MDS
Christopher A. Miller, Sridhar Nonavinkere Srivatsan, Michael H. Kramer, Sai Mukund Ramakrishnan, Catrina C. Fronick, Robert S. Fulton, Casey D. S. Katerndahl, Nichole Helton, Timothy James Ley, Matthew J. Walter
This paper uses long-read cDNA sequencing to identify novel transcripts and spliceosome-mutant-enriched isoforms in AML and MDS, providing a resource for improving short-read RNA-seq analyses.
bioRxiv · Jun 9, 2026 · PreprintCancer Biology