Author

Vinoth Sigamani

University of Tennessee Health Science CenterORCID 0000-0002-7545-3907Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Brian D. StrahliD· 1 shared Daniel L. JohnsoniD· 1 shared Mohd YousufiD· 1 shared R. Nicholas LaribeeiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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1 shared paperMolecular Biology

Brian D. StrahlORCID

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1 paper

Recent·Most cited

Chromatin stability safeguards mitochondrial homeostasis and prevents mTORC1 hyperactivation

Vinoth Sigamani, Mohd Yousuf, Daniel L. Johnson, Brian D. Strahl, R. Nicholas Laribee

The paper shows that chromatin stability prevents mTORC1 hyperactivation and mitochondrial stress during metabolic adaptation by maintaining histone integrity and regulating mitochondrial function.

bioRxiv · Dec 12, 2025 · PreprintMolecular Biology