R. Nicholas Laribee

The paper shows that chromatin stability prevents mTORC1 hyperactivation and mitochondrial stress during metabolic adaptation by maintaining histone integrity and regulating mitochondrial function.

This study shows that Ccr4-Not ubiquitin ligase activity maintains ribosomal protein homeostasis and inhibits 40S ribosomal autophagy through interactions with the endolysosomal pathway.