Daniel L. Johnson

The paper shows that chromatin stability prevents mTORC1 hyperactivation and mitochondrial stress during metabolic adaptation by maintaining histone integrity and regulating mitochondrial function.

This study identifies a cGAS-STING signaling loop driving neuroinflammation and tau pathology in tauopathies, showing its disruption can alleviate disease symptoms.

This study shows that Ccr4-Not ubiquitin ligase activity maintains ribosomal protein homeostasis and inhibits 40S ribosomal autophagy through interactions with the endolysosomal pathway.

The paper identifies 9 transcripts common to all PWS subtypes and finds reduced mitochondrial transcripts and defects in PW-UPD +ASD neurons, suggesting mitochondrial dysfunction may increase autism risk.