The paper identifies large chromosomal inversions in Lake Malawi cichlids and links them to habitat preference, lineage separation, and sex determination.

bioRxiv · Oct 28, 2024 · PreprintEvolutionary Biology

CRISPR knockouts of pmela and pmelb engineered a golden tilapia by regulating relative pigment cell abundance

Chenxu Wang, Jia Yin Xu, Thomas D. Kocher, Minghui Li, Deshou Wang

This study mutates pmela and pmelb in tilapia to show their roles in pigmentation, finding pmela has a greater impact on body color and RPE pigmentation than pmelb.

Journal of Heredity · Apr 6, 2022Peer-reviewedGenetics

Chromosome-scale assemblies reveal the structural evolution of African cichlid genomes

Matthew A. Conte, Rajesh Joshi, Emily C. Moore, Sri Pratima Nandamuri, William Gammerdinger, Reade B. Roberts, Karen L. Carleton, Sigbjørn Lien, Thomas D. Kocher

The paper compares chromosome-scale genome assemblies of African cichlids to identify structural variations and their evolutionary implications.

GigaScience · Apr 1, 2019Peer-reviewedGenomics

A High Quality Assembly of the Nile Tilapia (Oreochromis niloticus) Genome Reveals the Structure of Two Sex Determination Regions

Matthew A. Conte, William Gammerdinger, Kerry L. Bartie, David James Penman, Thomas D. Kocher

The paper presents a high-quality genome assembly of Nile tilapia, revealing structural details of sex determination regions in tilapia and a related species.

BMC Genomics · May 2, 2017Peer-reviewedGenomics