Deshou Wang

This study identifies the Dhh-Ptch2-Gli1-Sf1 signaling axis as critical for stem Leydig cell differentiation in Nile tilapia, showing Dhh regulates differentiation, Ptch2 acts as the receptor, Gli1 as the transcriptional effector, and Sf1 as the downstream effector.

This study mutates pmela and pmelb in tilapia to show their roles in pigmentation, finding pmela has a greater impact on body color and RPE pigmentation than pmelb.

The paper presents high-quality chromosome-level genomes of two tilapia species, revealing repeat sequence evolution and identifying a candidate female-determining gene.