Naoki Osato

The paper identifies pathway redistribution across cellular states using a framework combining co-expression data and deep learning, revealing shared signaling modules and context-dependent regulatory networks in RNA-binding proteins.

The paper identifies directional DNA motifs of DBPs associated with insulator function in human cells and supports the insulator-pairing model.

The paper identifies directional chromatin-associated regulatory motifs that influence gene expression in multiple cell types and tissues.

The paper characterizes the transcriptomic and epigenomic landscape of nine human endothelial cell types, identifying EC-specific enhancers and marker genes, and highlights the role of HOX genes in vascular development and disease.

The paper identifies human putative transcriptional target genes and shows they have significant functional enrichments related to cellular functions, with variations based on enhancer-promoter assignments and expression levels.