Youichiro Wada

The paper maps lineage trajectories and gene regulatory networks of cardiopharyngeal neural crest cells in mice, identifying a Hox-Meis-regulated transition associated with cardiac cushion development.

This paper develops a novel therapy for gastric cancer peritoneal dissemination using genetically modified dental pulp cells loaded with astatine-211, showing tumor regression and extended survival in mice.

The paper uses multimodal analysis to reveal cardiac neural crest lineage diversity and gene regulatory networks involved in their differentiation.

This study shows that Kdm7a regulates posterior Hox gene expression in mouse embryos by demethylating H3K9me2, leading to anterior-posterior developmental defects.

The paper shows that KDM7A and UTX demethylate repressive histone marks to enable NF-κB-dependent inflammatory gene activation in endothelial cells.

The paper characterizes the transcriptomic and epigenomic landscape of nine human endothelial cell types, identifying EC-specific enhancers and marker genes, and highlights the role of HOX genes in vascular development and disease.

The paper investigates the role of Dlx5/6 in cranial neural crest cells in determining jaw identity and symmetry, showing that their expression in NCCs is critical for lower jaw development and jaw matching.