Spen and Nito prevent dedifferentiation of progenitors by translationally repressing E(Spl)mγ
Xiaosu Li, Wenwen Lu, Marisa Connell, Xiaobing Deng, Sijun Zhu
The paper shows that Spen and Nito repress E(Spl)mγ translation in stem cells to prevent progeny dedifferentiation during asymmetric division.
bioRxiv · Aug 19, 2025 · PreprintDevelopmental Biology