Xiaosu Li

This study shows Med12 and Med13 prevent dedifferentiation of intermediate neural progenitors and loss of neural stem cells in Drosophila by regulating gene expression through interactions with different mediator complex subsets.

This study identifies how ERK, PKA, YAP/TAZ, and SHH signaling integrate to drive cortical lineage diversification and evolutionary expansion in the human cerebral cortex.

This study shows that Olig1/2 knockout in gliogenesis shifts glial precursor cells to produce non-proliferative interneurons instead of oligodendrocyte precursors, and identifies dorsal cortical GPCs as origin of H3.3G34R/V-mutant tumors.

This study uses scRNA-seq and snATAC-seq to show that radial glia sequentially generate neurons and glia through lineage progression, with chromatin accessibility regulating cell fate decisions.

The paper shows that Spen and Nito repress E(Spl)mγ translation in stem cells to prevent progeny dedifferentiation during asymmetric division.