EPHA1 and EPHB4 tyrosine kinase receptors regulate epithelial morphogenesis
Noémie Lavoie, Anaëlle Scribe, François J.-M. Chartier, Karim Ghani, Alexandra Jetté, Sara L. Banerjee, Manuel Caruso, Mélanie Laurin, Andrew Freywald, Sabine Elowe, Patrick Laprise, Nicolas Bisson
This study shows EPHA1 and EPHB4 regulate epithelial morphogenesis by controlling mitotic spindle orientation through ligand-dependent basolateral localization, independent of their catalytic activity.
bioRxiv · Jul 15, 2024 · PreprintCell Biology