Sabine Elowe

This study identifies ZNF768 as a regulator of E2F1 expression, which drives G0/G1 transition and cell cycle progression, with implications for cancer progression.

This study shows TEM4 regulates the cell cycle by controlling G1 progression through modulation of p21waf1/cip1 and cyclin B levels.

This study characterizes mitotic and centrosomal defects in a breast cancer continuum model, identifying increased chromosome segregation errors and centrosome abnormalities associated with disease progression.

This study shows EPHA1 and EPHB4 regulate epithelial morphogenesis by controlling mitotic spindle orientation through ligand-dependent basolateral localization, independent of their catalytic activity.

This study identifies novel effector proteins of EPH receptors and shows they regulate cell polarity and morphogenesis through PAR-3 and CSK signaling.

The paper identifies a type 2 diabetes disease module in endosomes, highlighting Cdk2 and PTPLAD1 as key hubs with new genetic and functional associations.