Nicolas Bisson

This study maps the acetyl lysine machinery interactions and identifies MAPKAPK2 as a factor contributing to resistance to BET bromodomain inhibitors in melanoma.

This study shows EPHA1 and EPHB4 regulate epithelial morphogenesis by controlling mitotic spindle orientation through ligand-dependent basolateral localization, independent of their catalytic activity.

This study identifies novel effector proteins of EPH receptors and shows they regulate cell polarity and morphogenesis through PAR-3 and CSK signaling.

The paper shows that SH3 domain specificity in PPIs is influenced by host protein identity and domain position, not just intrinsic domain properties.