The paper constructs an E2F-based prognostic model for HCC, revealing single-cell immune heterogeneity and its association with patient survival and tumor progression.

Journal of Biological Chemistry · Jan 25, 2023Peer-reviewedBioinformatics

De novo mutations involved in post-transcriptional dysregulation contribute to four neuropsychiatric disorders

Fengbiao Mao, Lu Wang, Xiaolu Zhao, Zhongshan Li, Luoyuan Xiao, Rajesh C. Rao, Jinchen Li, Huajing Teng, Xin He, Zhong Sheng Sun

The paper identifies de novo mutations affecting post-transcriptional regulation that contribute to four neuropsychiatric disorders.

bioRxiv · Nov 26, 2019 · PreprintGenomics

A statistical framework for mapping risk genes from de novo mutations in whole-genome sequencing studies

Yuwen Liu, Yanyu Liang, A. Ercüment Çiçek, Zhongshan Li, Jinchen Li, Rebecca Muhle, Martina Krenzer, Yue Mei, Yan Wang, Nicholas Knoblauch, Jean Morrison, Siming Zhao, Yi Wei Jiang, Evan T. Geller, Iuliana Ionita‐Laza, , Xin He

This paper introduces a statistical framework to identify risk genes from de novo mutations in whole-genome sequencing studies, finding new autism risk genes.

The American Journal of Human Genetics · May 10, 2018Peer-reviewedGenetics

TET1 Modulates H4K16 Acetylation by Interacting with hMOF to Regulate Expression of DNA Repair Genes and Oncogenic Transformation

Jianing Zhong, Xianfeng Li, Wanshi Cai, Yan Wang, Shanshan Dong, Jian’an Zhang, Jie Yang, Kangli Wang, Fengbiao Mao, Cheng Zeng, Yuanyuan Li, Jinyu Wu, Huanming Yang, Xingzhi Xu, Zhong Sheng Sun

bioRxiv · Aug 17, 2015 · PreprintMolecular Biology