Fengbiao Mao

This paper identifies and engineers a miniature CRISPR-Cas12m variant for epigenome editing, demonstrating its effectiveness in human cells and a mouse model of HBV infection.

This paper develops CIRCMIP to profile intratumoral microbiota, identifies Staphylococcus lugdunensis as a bladder cancer biomarker, and reveals its metabolic role via LPC14:0-PPARδ signaling.

The paper shows that DNA demethylation, mediated by TET enzymes, is essential for rod-photoreceptor fate determination during retinal development.

This study identifies granulin+ macrophages as drivers of lineage plasticity in prostate cancer through paracrine signaling loops, promoting drug resistance.

The paper constructs an E2F-based prognostic model for HCC, revealing single-cell immune heterogeneity and its association with patient survival and tumor progression.

The paper identifies de novo mutations affecting post-transcriptional regulation that contribute to four neuropsychiatric disorders.