Michael T. Taylor

This paper develops a photosensitized strategy for protein labelling using N-substituted pyridinium salts and a quinolinium scaffold, achieving efficient labelling in minutes with high selectivity for tryptophan residues.

The paper describes a simple chemical synthesis method for Fmoc-protected α-hydroxyglycine dipeptides and demonstrates their functionalization with non-natural amino acids.

This paper designs aromatic cation salts that enable photo-induced protein labelling and imaging using longer wavelengths of light, achieving robust reactivity in live cells.