Organic & Biomolecular ChemistryBiochemistryPeer-reviewed journal article
Simple synthesis and functionalisation of α-hydroxyglycine-containing peptide fragments
Pooja R. Solanke, Debolina Sarkar, Pranab Chandra SahaiD, Michael T. TayloriD
Abstract
We report here a method for the chemical synthesis of Fmocprotected -hydroxyglyine (-OH-Gly) dipeptides. Our method features operational simplicity and is compatible with protecting groups for peptide synthesis. Utility is then demonstrated through substitution at the -OH-Gly position to yield myriad non-natural amino acid-containing dipeptide fragments.
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