TCR signaling via NFATc1 constrains IL-15-induced NK-like activation of human memory CD8+ T cells
Hoyoung Lee, Soyoung Kim, Sang-Hoon Kim, Seongju Jeong, Kyung Hwan Kim, Chang Gon Kim, June‐Young Koh, Hyung‐Don Kim, Ji Won Han, Hosun Yu, Sunwoo Min, Su‐Hyung Park, Hyuk Soo Eun, Eui‐Cheol Shin
This study identifies NFATc1 as a suppressor of IL-15-induced NK-like activation in human memory CD8+ T cells via the Ca2+-calcineurin pathway and defines a gene signature associated with bystander activation.
bioRxiv · Jan 13, 2025 · PreprintImmunology