Epistatic impacts of cis- and trans-regulatory mutations on the distribution of mutational effects for gene expression in Saccharomyces cerevisiae
Eden W. McQueen, Bing Yang, Patricia Jean Wittkopp
The paper examines how cis- and trans-regulatory mutations affect the distribution of mutational effects on gene expression in yeast, finding changes in variance and skewness that influence mutational robustness and compensatory potential.
Molecular Biology and Evolution · Jul 16, 2026Peer-reviewedEvolutionary Biology