Patricia Jean Wittkopp

The paper identifies cis-regulatory changes in the TDH3 promoter that increase expression in S. cerevisiae by altering transcription factor interactions, while preserving expression dynamics.

The paper identifies miRNAs that regulate body pigmentation in adult Drosophila melanogaster through gain- and loss-of-function screens and validates miR-8's role in modulating pigmentation genes.

The paper examines how cis- and trans-regulatory mutations affect the distribution of mutational effects on gene expression in yeast, finding changes in variance and skewness that influence mutational robustness and compensatory potential.

The paper analyzes RNAseq data from yeast species to study how regulatory networks controlling gene expression plasticity evolve in response to environmental changes.

The paper examines how environmental factors influence gene expression noise and its fitness effects in yeast, showing environment-specific relationships.

The paper identifies trans-acting mutations in yeast that modulate gene expression noise in both intrinsic and extrinsic ways, revealing non-nuclear factors influencing nuclear gene expression.

The paper investigates pigmentation variation in Drosophila elegans by identifying cis-regulatory changes in the ebony gene that contribute to intraspecific and interspecific color morph differences.

The paper uses structural similarity to identify and design proteasome chaperone proteins in Candida auris, showing conservation of function despite sequence divergence.

The paper identifies a micro-RNA, mir-193, as the effector gene responsible for melanic wing color polymorphisms in Lepidoptera, showing its conserved function across species.

The paper examines how gene expression and fitness relationships vary across environments in yeast, showing environment-specific effects of mutations on gene expression and fitness.

The paper compares the effects of Drosophila and C. elegans Grainy head orthologs on chromatin accessibility, gene expression, and embryonic viability in Drosophila, showing functional divergence despite conserved developmental roles.

The paper identifies trans-regulatory mutations affecting gene expression in S. cerevisiae and shows their genomic distribution overlaps with segregating variants.

This study shows that the pigmentation genes ebony and tan in Drosophila also influence cuticular hydrocarbon composition, with loss-of-function mutants showing distinct CHC profiles.

The paper quantifies mutation effects on TDH3 promoter activity in yeast across environments and finds natural selection limits plasticity between glucose and galactose.

The paper assesses how mutations in the TDH3 promoter of Saccharomyces cerevisiae affect cell growth and predicts fitness consequences of these variants.