Loïc Bideau

This study investigates Notch signaling's role in post-embryonic neurogenesis in Platynereis dumerilii, showing its regulation of progenitor specification, differentiation, and neurogenic balance during regeneration and elongation.

The paper identifies two progenitor populations in Platynereis regeneration, showing that less differentiated, more proliferative gut progenitors are more plastic but limited in regenerative capacity.

The paper generates a high-quality reference transcriptome for Platynereis dumerilii and analyzes RNA-seq data from posterior regeneration stages to identify gene expression dynamics and key molecular mechanisms.

This study shows that brain hormones, specifically methylfarnesoate, are essential for posterior regeneration in Platynereis dumerilii, and their absence after decapitation impairs regeneration.