Systematic evaluation of the impact of promoter proximal short tandem repeats on expression
Xuan Zhang, Zhang Lingzhi, Ellice Wang, Susan M. Benton, Eduardo Modolo, Mikhail Maksimov, Sharona Shleizer-Burko, Qingqing Gong, Catherine Wang, Michael Lamkin, Eric M. Mendenhall, Melissa Gymrek, Alon Goren
This study evaluates how promoter proximal short tandem repeats (STRs) affect gene expression using MPRA, identifying key factors like repeat unit sequence and copy number.
bioRxiv · Sep 14, 2025 · PreprintGenomics