Thrombospondin 2 is a key determinant of fibrogenesis in NAFLD
Takefumi Kimura, Takanobu Iwadare, Shun‐ichi Wakabayashi, Seema Kuldeep, Tomoyuki Nakajima, Tomoo Yamazaki, Daiki Aomura, Hamim Zafar, Mai Iwaya, Takeshi Uehara, Sai Prasad Pydi, Naoki Tanaka, Takeji Umemura
The paper identifies THBS2/TSP2 as a key driver of fibrogenesis in NAFLD by showing its expression in HSCs and its role in collagen activation, suggesting it as a potential anti-fibrotic target.
bioRxiv · Jun 1, 2023 · PreprintMolecular Biology