Author

Seema Kuldeep

Indian Institute of Technology Kanpur

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Hamim ZafariD· 3 shared Sai Prasad PydiiD· 3 shared Ashish KumariD· 2 shared H.N. Yadav· 2 shared Rashmi ParihariD· 2 shared Simran Singh· 2 shared Sonal Amit· 2 shared Soumita Bhaumik· 2 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPhysiology

Hamim ZafarORCID

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3 papers

Recent·Most cited

Myeloid Gi signaling acts as a weight-independent immunometabolic switch controlling systemic insulin sensitivity

Seema Kuldeep, H.N. Yadav, Seema Riyaz, Soumita Bhaumik, Shruti Agarwal, Aishi Satapathy, Simran Singh, Ashish Kumar, Sudipta Paul, Monika Patel, Mriganka De Sarkar, Raashidha Farhath, Sonal Amit, Rashmi Parihar, Hamim Zafar, , Sai Prasad Pydi

This paper identifies myeloid Gi signaling as a weight-independent immunometabolic switch that regulates systemic insulin sensitivity through opposing cytokine programs.

bioRxiv · Mar 31, 2026 · PreprintPhysiology

Acute activation of Gq-signaling in islet macrophages inhibits β-cell insulin secretion through AMPK-sphingolipid axis

Simran Singh, Ashish Kumar, Sudipta Paul, Mriganka Sarkar, Santhosh Duraisamy, H.N. Yadav, Seema Kuldeep, Soumita Bhaumik, Kunj Kumar Prajapati, Saahiba Thaleshwari, Anuj Gargya, Tamojit Santra, Sonal Amit, Rashmi Parihar, Santosh Kumar Misra, , Sai Prasad Pydi

This study shows that activating Gq-signaling in islet macrophages impairs β-cell insulin secretion via the AMPK-sphingolipid axis, revealing a new immune-endocrine communication mechanism.

bioRxiv · Oct 29, 2025 · PreprintPhysiology

Thrombospondin 2 is a key determinant of fibrogenesis in NAFLD

Takefumi Kimura, Takanobu Iwadare, Shun‐ichi Wakabayashi, Seema Kuldeep, Tomoyuki Nakajima, Tomoo Yamazaki, Daiki Aomura, Hamim Zafar, Mai Iwaya, Takeshi Uehara, Sai Prasad Pydi, Naoki Tanaka, Takeji Umemura

The paper identifies THBS2/TSP2 as a key driver of fibrogenesis in NAFLD by showing its expression in HSCs and its role in collagen activation, suggesting it as a potential anti-fibrotic target.

bioRxiv · Jun 1, 2023 · PreprintMolecular Biology