Sai Prasad Pydi

This study shows that TGR5 agonism expands hippocampal neural stem cells, reduces senescence, and improves cognitive function in aged mice without promoting neuronal differentiation.

This paper identifies myeloid Gi signaling as a weight-independent immunometabolic switch that regulates systemic insulin sensitivity through opposing cytokine programs.

This study shows that activating Gq-signaling in islet macrophages impairs β-cell insulin secretion via the AMPK-sphingolipid axis, revealing a new immune-endocrine communication mechanism.

This study maps dynamic changes in murine pancreatic islet cell composition and transcriptional states during hyperglycaemia progression using single-cell multi-omics data.

This study shows that amylin aggregates faster on fibrillar collagen, leading to β-cell death and dysfunction, which accelerates diabetic progression.

This study shows that SARS-CoV-2's ORF3a protein induces lysosomal membrane atg8ylation, which protects cells from death by limiting ORF3a-induced cell death.

The paper identifies THBS2/TSP2 as a key driver of fibrogenesis in NAFLD by showing its expression in HSCs and its role in collagen activation, suggesting it as a potential anti-fibrotic target.