Induction and long-term maintenance of hindbrain-like neural stem cells in xeno- and basic fibroblast growth factor-free conditions
Ziadoon Al-Akashi, Denise Zujur, Nicholas Boyd-Gibbins, Nathalie Eileen Wiguna, Masato Nakagawa, Tetsuhiro Kikuchi, Asuka Morizane, Jun B. Takahashi, Makoto Ikeya
This study generates and maintains hindbrain-like neural stem cells without xeno- or basic fibroblast growth factors using three chemicals, showing long-term stability and potential for disease modeling and therapy.
bioRxiv · Mar 3, 2025 · PreprintCell Biology